NutriLeads Completes 4.5 Million Euro Series C Financing to Accelerate Commercialization of BeniCaros as a Global Precision Prebiotic Brand

Company also announces Board and Management changes and new scientific advisory board

December 18, 2023 – NutriLeads BV today announced that it has raised 4.5 million euros in a Series C investment round to accelerate the commercialization of BeniCaros®, the company’s award-winning precision prebiotic fiber for enhancing immune and gut health. The financing was led by existing investor dsm-firmenich Venturing with the support from the other current investors. The funding will support expansion in new consumer markets and geographies, and the creation of a global brand for this innovative food, beverage and dietary supplement ingredient.

“BeniCaros offers health benefits for consumers of all ages,” said Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer. “And this funding will enable us to move into key market regions with strong consumer demand for natural immune and gut health solutions and drive research to substantiate additional differentiating product claims.”

In conjunction with the successful completion of the Series C financing, the company announced a new single-tier board structure. The Board consists of Dr. Carneiro (CEO), Alexander Belderok (Chair), Florentine Fockema Andreae and two new members: Akshat Kshetrapal, an Investment Director at dsm-firmenich Venturing, and Bibilotte Duyvesteyn, a specialty nutrition value chain consultant.

“The financing and Board changes support the transition of NutriLeads into a fully commercial company with an emerging global brand of tremendous potential in the health ingredients market,” said Dr. Carneiro. “Combined with the additional capital, NutriLeads is well positioned for strong sales growth and profitability.”

NutriLeads also announced that its Founder Ruud Albers, Ph.D. will transition from his current role as Chief Scientific Officer to become chair of NutriLeads’ newly established Scientific Advisory Committee. This committee will provide guidance for NutriLeads’ research and development initiatives.

“I’m extremely proud and thankful of what we have accomplished together; from the original discovery of an active compound to the production and commercialization of BeniCaros,” said Dr. Albers. “I’m looking forward to continuing to advise NutriLeads on relevant technological and scientific matters while also pursuing new personal adventures. I wish Joana and the team success in driving NutriLeads to the commercial success it deserves.”

“We thank Ruud for his invaluable contributions to the company, and we look forward to a collaborative future with him,” said Dr. Carneiro. Added by Board Chairman Alexander Belderok: “Ruud’s transition to this new advisory role will ensure that his wealth of expertise in immunology, gut health and BeniCaros remains a vital resource for NutriLeads.”

BeniCaros is a precision prebiotic from upcycled carrot pomace. It is clinically proven to train smarter, faster and stronger innate immune responses and to consistently improve microbiota composition for a more resilient gut ecosystem essential for health and wellness. This research supports a variety of compelling product claims. The science of BeniCaros, along with its remarkably small daily serving size (as low as 300 mg.) and attractive formulation profile, creates numerous product innovation opportunities for food, beverage and supplement companies.

“We will continue to develop additional health applications for BeniCaros in human health and nutrition and look for development partnerships with pet and animal nutrition companies,” said Dr. Carneiro.

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NutriLeads and FMCG Gurus Webinar Exploring Untapped Prebiotic Market Opportunities Set for Dec. 5

November 16, 2023 – NutriLeads BV and FMCG Gurus will host a webinar on consumer trends and product opportunities in the prebiotic market at 10:00am EST on Tuesday, December 5. Registration is now open for the one-hour webinar, which will be held at 16:00 CET / 10:00 EST on December 5th.

The “Navigating the Prebiotic Boom for Health and Wellness” webinar will feature three experts from the fields of consumer research, prebiotics and natural products manufacturing. They will explore consumer awareness, understanding and usage of prebiotics, as well as the uncovering of untapped market opportunities. They will also delve into the world of prebiotics – their definition, mechanisms and crucial distinctions that show not all prebiotics are the same.

“The webinar will share valuable insights for formulators and manufacturers of products designed to promote a healthy gut microbiota and other aspects of health and well-being,” said Ruud Albers, Chief Science Officer of NutriLeads. “These insights will support efforts to create new products that contribute to optimal health.”

The webinar will feature three speakers:

  • Mike Hughes, Head of Research and Insights, FMCG Gurus. Mike has over 15 years of experience analyzing consumer trends, attitudes and behaviors and currently leads the research and insight division at FMCG Gurus. He has a particular interest in highlighting how consumer attitudes and behaviors can often differ and what the true meaning of trends are for the industry.
  • Ruud Albers, Ph.D., founder and Chief Science Officer of NutriLeads, manufacturer of award-winning precision prebiotic BeniCaros®. Upcycled from carrot pomace, BeniCaros has dual mechanism of action that consistently modulates healthy gut microbiota composition and trains faster, smarter and stronger innate immune responses.
  • Patrick Firlik, founder and Chief Executive Officer of Well Traveled Health Inc., manufacturer of Well Traveled Immune Activator, a dietary supplement to help consumers stay well amid the stress and toll that travel takes on diet, sleep, hydration, personal routines and the immune system. The product combines pre- and postbiotics, vitamin C and zinc.

Register here for attending the webinar.

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Fast Food or Fine Dining for Gut Microbiota? NutriLeads Presentation on Precision Prebiotics Set for SupplySide West Annual Trade Show on Oct. 25

September 26, 2023 – NutriLeads BV will present research demonstrating the importance of prebiotic fiber structure to producing consistent, predictable gut health benefits at 11:00 a.m. on October 25th at the SupplySide West Supplier Presentation Theater, booth #3077. SupplySide West, an international gathering of health and nutrition industry professionals, will be held from October 23-27 at Mandalay Bay, Las Vegas.

Despite their tremendous commercial success, prebiotic benefits for the general population largely depend on the host microbiota composition that differs between healthy individuals. At SupplySide West, Ruud Albers, Ph.D., NutriLeads’ founder and Chief Scientific Officer, will discuss research showing the diverse impact of prebiotic fibers with varying levels of structural complexity on the gut microbiota.  Scientific evidence suggests prebiotic fiber structure is critical for producing consistent, predictable gut health benefits in varying individual gut ecosystems.  Dr. Albers’ presentation is titled, “Is Your Prebiotic Fast Food or Fine Dining?”

“Not all prebiotic fibers are alike,” said Dr. Albers. “Prebiotics with simple structures that can be fermented or eaten by virtually all microorganisms in the gut are like fast food – the benefits may be inconsistent or limited. Research shows that fibers with just the right specificity, like BeniCaros, promote the growth of beneficial bacterial species, regardless of the existing variations in individuals’ gut microbiota composition.”

NutriLeads manufactures the award-winning precision prebiotic BeniCaros® from upcycled carrot pomace. Scientifically known as Rhamnogalacturonan-I (RG-I), BeniCaros is clinically proven to train the innate immune system to respond smarter, faster and stronger. It also consistently and specifically modulates the composition of the gut microbiota to support a resilient gut ecosystem essential for a strong immune function and overall health.

NutriLeads will showcase BeniCaros in gummy products that SupplySide West attendees can sample at its booth, #3341.  NutriLeads senior managers will be available to discuss the science of BeniCaros as well as commercial applications. BeniCaros’ small daily serving size of only 300 mg and its favorable formulation profile – tasteless, odorless, water soluble and heat/pH stable – make it a game-changer for innovative immune and gut health product applications and formats.

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Precision Prebiotic BeniCaros® Wins World Plant-Based Health Innovation Award

September 8, 2023 – BeniCaros®, a low-dose precision prebiotic from NutriLeads BV, was named best product in the Health Innovation category at the World Plant-Based Innovation Awards yesterday at the Plant Based World Expo in New York City. BeniCaros was also a finalist in the Ingredient Innovation category.

The awards celebrate innovation and excellence across the plant-based food and beverage industry. The 2023 competition included over 140 entries from 20 countries across 17 categories.

“At NutriLeads, we are committed to helping dietary supplement and functional food and beverage manufacturers create innovative, multifunctional products with clinically proven, upcycled ingredients that contribute to a healthier world, naturally,” said Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer. “We are honored to accept this award, which recognizes the game-changing potential of BeniCaros for immune and gut health.”

BeniCaros is clinically proven to train smarter, faster and stronger innate immune system responses. It also consistently and specifically modulates the composition of the gut microbiota for a resilient gut ecosystem that is essential for strong immune function and overall health and well-being. These health benefits are delivered in a small 300 mg daily serving that creates broad product innovation opportunities.

BeniCaros is produced from upcycled carrot pomace and has a formulation profile (tasteless, odorless, water soluble and heat/pH stable) suitable for most foods, beverages and dietary supplements.

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NutriLeads’ Prebiotic BeniCaros Notified for Immune Health Claims in Australia and New Zealand Foods, Beverages and Supplements

August 29, 2023 – Following a systematic review of the scientific evidence supporting BeniCaros®, NutriLeads’ clinically proven precision prebiotic fiber from upcycled carrot pomace, eight self-substantiated food health relationships have been submitted to Food Standards Australia and New Zealand (FSANZ). The general level health claims were made in collaboration with NutriLeads’ Australia and New Zealand distribution partner, Pathway International Pty Ltd.

“The FSANZ claims mean manufacturers in Australia and New Zealand can include them on the labels of their food and beverage products,” said Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer. “It sends a clear message to consumers that the health benefits of BeniCaros are scientifically substantiated.”

The FSANZ claims, which are based on the results of peer-reviewed randomized clinical research, are as follows:

  • Supports/aids/assists/promotes/boosts/stimulates/improves immune health
  • Reduces the severity and duration of symptoms of common cold (rhinovirus) infection
  • Stimulates innate immune and anti-viral response to common cold (rhinovirus) infection
  • Faster and more effective immune response
  • Supports immune defenses
  • Supports healthy immune system function and response
  • Accelerates local protective anti-viral immune response
  • Immunomodulatory effect on immune cells

In addition to the FSANZ claims, BeniCaros is permitted for use in dietary supplements regulated by Australian Therapeutic Goods Administration (TGA), without restrictions.

BeniCaros®, a plant-based, award-winning, precision prebiotic fiber known scientifically as RG-I (Rhamnogalacturonan-I), has a dual mechanism of action. At a very low 300 mg. daily serving size, BeniCaros trains the innate immune system to respond smarter, faster and stronger. It also consistently and selectively increases beneficial gut microorganisms, with minimal gas production, despite preexisting variation in individual gut microbiota composition. This supports a robust gut ecosystem that is essential to a strong immune system and overall health.

“BeniCaros creates new opportunities for product innovation in the immune and gut health marketplace,” said Wayne Coote, Managing Director of Pathway International, which represents BeniCaros in the Australian and New Zealand markets. “The ingredient has remarkable health benefits, formulation properties and now notified label claims.”

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NutriLeads to Present Research on Gut and Immune Health at Vitafoods Asia, Sept 21

BeniCaros prebiotic gummy samples available at NutriLeads display #J34, Hall 6.

NutriLeads’ founder and Chief Scientific Officer, Ruud Albers, Ph.D., is set to deliver a presentation on supporting the immune system through the gut at 11:30 a.m. on September 21st in the NutraFocus Zone during VitaFoods Asia in Bangkok, Thailand. Vitafoods Asia is a prestigious three-day event (Sept 20-22) that brings together leaders from the nutraceutical, food, and beverage industry.

BeniCaros effectively influences innate immune cells, training them for accelerated responses to future challenges. A randomized clinical study demonstrated BeniCaros significantly reduced the severity and duration of symptoms following a controlled challenge with a common cold virus. Additionally, BeniCaros consistently promotes the growth of beneficial bacterial species, such as Bifidobacterium spp. (B. longum and B. adolescentis), regardless of the existing variations in individuals’ gut microbiota composition. A recent SIFR® study involving 24 subjects has provided evidence that BeniCaros significantly enhances the production of short-chain fatty acids (acetate, propionate, and butyrate) with lower gas production compared to inulin.

“Consumers increasingly recognize the profound and crucial link between immune and gut health,” said Dr. Albers. “Innovative nutritional interventions like BeniCaros that enhance both aspects will enable solutions that meet these top consumer health priorities.”

NutriLeads Display and Product Samples

NutriLeads will host a booth (# J34) at VitaFoods Asia and offer gummy samples of BeniCaros. Each gummy contains an effective daily serving of 300 mg. of BeniCaros.

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Body Ecology Reformulates Prebiotic Supplement for Immune,  Gut and Digestive Health Benefits with BeniCaros® from NutriLeads® BV  

July 6, 2023 – Body Ecology has reformulated its dietary supplement EcoBloom™ as a prebiotic blend with award-winning BeniCaros® from NutriLeads BV. EcoBloom supports a stronger, faster immune system, a healthy gut microbiome and improved digestive health. 

“Most of us don’t eat enough natural fiber or have a hard time digesting it due to infections in the small intestine. EcoBloom™ helps ensure our body’s inner ecosystem gets the essential support needed for optimal digestive health,” said Donna Gates, M.Ed., ABAAHP, founder of Body Ecology. “And very importantly in this day and age, BeniCaros helps train and strengthen the body’s natural defenses—enabling smarter and faster immune responses.” 

The recommended daily serving of EcoBloom contains: 

  • BeniCaros (300 mgs), a soluble, precision prebiotic fiber scientifically known as RG-I (Rhamnogalacturonan-I). Its medium to high specificity molecular structure creates a dual mechanism that trains innate immune cells to respond more quickly when challenged and targets specific beneficial gut microorganism to increase production of metabolites that support immune health. 
  • Acacia fiber (3000 mgs), a soluble prebiotic fiber from the sap of the acacia tree that is native to parts of India, Africa and Pakistan. It is easy to digest and promotes healthy elimination. 
  • Sunfiber (3000 mgs), a galactomannan based soluble dietary and prebiotic fiber made from hydrolyzed guar gum from the Indian guar bean that supports digestive health and microflora balance. 

“We are thrilled to have BeniCaros as part of this innovative product from a company known for helping consumers achieve their health goals through diet and support of the complex gut ecosystem, the microbiome,” said Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer. “BeniCaros is clinically proven to selectively nourish beneficial gut microorganisms and train the innate immune system to be smarter and faster.” 

For more information about EcoBloom, including purchase options, visit the Body Ecology website

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NutriLeads Receives Perfect Score on International Food Safety Certification

May 31, 2023 – NutriLeads scored a perfect 100% on its food safety certification, demonstrating its compliance with the requirements of the International Featured Standard Broker (IFS) in food safety and quality. IFS is a Global Food Safety Initiative benchmarked standard for all aspects of food and ingredient manufacturing.

“Improving consumer health is our mission and meeting the highest standards for food safety and quality is our top priority,” said Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer. “Everyone at NutriLeads is committed to exceeding high standards for safety and quality for our ingredients, from farm to finished products.”

The certification follows an independent IFS broker audit that evaluated NutriLeads’ compliance with international safety standards for product sourcing, supply chain, manufacturing and after-care for customers.

Marie-Jose Hendriks, QA Manager at NutriLeads adds: “This audit result shows NutriLeads has implemented all appropriate measures, from production to sales, assuring our high quality standards. Everyone within NutriLeads takes quality into account within their daily activities to make sure our customers receive what they expect. For this reason I believe NutriLeads deserves the 100% score it got”.

IFS certification is recognized worldwide. The certification demonstrates that NutriLeads is a trustworthy ingredient supplier and partner for manufacturers and consumers.

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NutriLeads’ BeniCaros Strengthens Healthy Gut Microbiota, Study Shows

May 2, 2023 – An ex vivo study has demonstrated that BeniCaros®, an upcycled soluble carrot fiber from NutriLeads BV, has the right level of structural complexity to produce consistent, significant and beneficial effects on the gut microbiota despite differences in individual microbiota composition. This unique precision prebiotic robustly stimulated growth of common beneficial gut bacteria, significantly increased metabolite production and ultimately created a more consistent gut microbiota composition among healthy subjects. The results were recently published in the peer-reviewed journal, Nutrients.

“It is remarkable that a small serving of only 300 milligrams of BeniCaros can display such consistent prebiotic effects despite the fact that composition of gut microbiota is unique to every individual,” said Annick Mercenier, Ph.D., NutriLeads co-founder and Senior Director R&D. “Variability in the gut microbial communities in individuals renders it challenging to demonstrate efficacy of functional ingredients. The high consistency effect of BeniCaros on microbial composition and metabolite production could support more predictable health effects.”

Unprecedented Study Protocol

This new study compared the prebiotic effects of three dietary fibers of various specificity (i.e., structural complexity) on the intestinal microbiota of healthy adults. Fecal samples of each subject were incubated for 48 hours with 0.3 grams and 1.5 grams doses of BeniCaros, a carrot-derived rhamnogalacturonan I or cRG-I (medium-high specificity), 1.5 grams of inulin (low specificity) and 1.5 grams of xanthan (high specificity). High-throughput ex vivo SIFR® technology from Cryptobiotix SA, a validated gut digestion and fermentation simulator that generates predictive insights for clinical findings, was used to measure changes in gut microbiota composition and function. “This innovative technology enabled analysis of 24 individuals, an unprecedented number of subjects compared with the commonly used in vitro gut models,” said Dr. Mercenier.

Key Findings: BeniCaros has Precision Prebiotic Activity

The results illustrated how the specificity or complexity of dietary fiber structures determine which bacterial communities can ferment and benefit from a dietary intervention. Precision targeting of specific beneficial bacteria common in the core human microbiome could help ensure consistent prebiotic health benefits across diverse populations.

  • cRG-I selectively stimulated taxa or species of bacteria that were consistently present among human adults, resulting in lower microbiota composition differences between subjects. The homogenizing effect of cRG-I on the gut microbiota was dose-dependent. In contrast, both inulin and xanthan increased interpersonal differences.

BeniCaros significantly increased a broad spectrum of 30 operational taxonomic units (OTUs) belonging to Bifidobacteriaceae (2), Bacteroidaceae (4), Acidaminococcaceae (1), unclassified Clostridiales (1), Lachnospiraceae (18), Ruminococcaceae (3), and Veillonellaceae (1), including OTUs of health-related species such as Bifidobacterium longum, Bifidobacterium adolescentis, Anaerobutyricum hallii and Faecalibacterium prausnitzii.

“The goldilocks principle applies to BeniCaros,” said Ruud Albers, Ph.D., NutriLeads cofounder and Chief Scientific Officer. “Its structure is not so simple that it can be fermented by multiple bacterial strains in the gut, nor is it so complex that it can only be used by few microbial communities. RG-I’s specificity is just right.”

  • All three test compounds significantly increased production of short chain fatty acids (acetate, propionate and butyrate) that play an important role in host-microbiome “cross talk” and that modulate many human bodily functions, including the immune system. However, BeniCaros led to higher and more inter-individual consistent levels of SCFA than the other fibers.

Importantly, BeniCaros also demonstrated notably lower gas production than the two other studied fibers.  A limitation of prebiotics when large daily serving sizes (10-20 grams) are recommended is that they may cause bloating, gas and gut discomfort in sensitive people.

“Our research clearly demonstrates the game-changing potential of BeniCaros,” said Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer . “Its superior ability to consistently and beneficially modulate the gut microbiota enables product differentiation and BeniCaros’ very small serving size opens the door to innovation in functional foods, beverages and supplements.”

The current research paper is titled, Carrot RG-I Reduces Interindividual Differences between 24 Adults through Consistent Effects on Gut Microbiota Composition and Function Ex Vivo.

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Well Traveled Launches Immune Support Supplement with BeniCaros®

NutriLeads’ prebiotic carrot fiber helps power convenient, science-based solution for travelers

Well Traveled Health Inc. has launched Immune Activator dietary supplement with BeniCaros® from NutriLeads BV to help consumers stay well amid the stress and toll that travel takes on diet, sleep, hydration, personal routines and the immune system.

“As a management consultant constantly on the road, I never felt my best. I decided to make a clean and clinically validated immune support supplement that could help the modern traveler stay well on the road,” said Patrick Firlik, Well Traveled Founder and Chief Executive Officer. “With the help of nutrition experts, we created a ‘best-of-the-best’ solution that blends five complementary, science-based immune health ingredients in a great-tasting drink mix.”

Well Traveled Immune Activator strengthens the body’s natural defenses and accelerates immune responses. Its Fresh Lemon-flavored packets are powered by:

  • BeniCaros®, the award-winning, clinically proven immune-support ingredient from upcycled carrot pomace. This soluble carrot fiber with prebiotic properties trains the immune system to be faster, smarter and stronger. BeniCaros prepares immune cells for accelerated responses and selectively increases beneficial gut microorganisms and their metabolites that support immune health.
  • IMMUSE™ LC-plasma, a postbiotic that proactively supports the immune system through a novel method of activation of pDC (plasmacytoid dendritic cells) that in turn modulates pivotal immune cells, including NK, Killer-T, Helper-T, and B cells. IMMUSE, a product of Kyowa Hakko, is backed by 30 published studies, including 15 human clinical trials.
  • Vitamins C (from acerola fruit) and D3 (from algae), which research demonstrates supports immune cell health and immune system regulation.
  • Zinc (from guava leaf) that is essential for the healthy development and function of immune cells.

“We believe the combination of strong science and branded ingredients creates a unique product that delivers real immune health benefits and stands out in a crowded marketplace,” said Firlik.

Joana Carneiro, Ph.D., NutriLeads Chief Executive Officer, commented: “Consumers today are looking for multifunctional supplements to help them proactively stay healthy. BeniCaros’ microbiota-immune axis dual mechanism of action and small serving size enable our customers to formulate products that help consumers achieve their health goals.”

Well Traveled Immune Activatorwith BeniCaros® can be purchased on the Well Traveled website at www.gowelltraveled.com.

These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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